Cellular implantation therapy has recently been considered as an effective treatment for myocardial infarction, severe heart failure, and other disorders refractory to conventional treatments. Yet, there are still a number of problems that we must overcome.
1) Preparation of Cellular Medicine Products
Currently, implanting cells must be processed in the cell processing center (CPC). We are developing more convenient cell processing devices with sufficient purity, high yield, improved safety and reduce costs.
2) Development of Cell Administration Methods
Currently, surgical operations or sophisticated electrical mapping are necessary to administer implanting cells to the appropriate sites of infarcted myocardium. We are developing the cell injection catheter with minimal invasiveness and increased efficiency.
3) Establishment of Therapy
To increase the applicability of cellular implantation for common disorders, the qualities and viability of implanting cells must be kept consistent.
Our R&D specifically targets regenerative medicine on vascular and cardiac disorders, based upon our own cardiomyocyte research and collaboration with academic institutes. Aimed at developing novel therapies for ischemic heart diseases, our approach comprises the following three strategies.
1) On-site Cell Purification Devices
Bone marrow cells are used for cardiac and vascular regenerative therapy. To obtain mononuclear cells from bone marrow aspirates, we are developing the most convenient devices that efficiently harvest effective cells separated from harmful cell populations.
2) Cell Injection Catheter
We are developing a catheter system for administering implanting cells into the sites of infarcted myocardium. This catheter is percutaneously introduced into the coronary arteries with more sufficient safety and less invasiveness than conventional catheters.
3) Cellular Sheet
We are developing cellular sheets for cardiac implantation by culturing skeletal myoblasts on special dishes. This cell-sheet is expected to provide higher engraftment and therapeutic effects.